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European Network of Centres for Pharmacoepidemiology and Pharmacovigilance

About us


ENCePP aims to strengthen the monitoring of the benefit-risk balance of medicinal products in Europe by:

  • Bringing together capacity and expertise in pharmacoepidemiology and pharmacovigilance across Europe and providing a platform for collaborations;
  • Facilitating the conduct of high-quality, multi-centre, independent non-interventional studies (NIS);
  • Developing and maintaining methodological standards and governance principles for research in pharmacovigilance and pharmacoepidemiology;
  • Providing a network of excellence in pharmacoepidemiology that can be leveraged in public health emergencies.

ENCePP provides a unique opportunity for collaboration to improve pharmacoepidemiological research and benefit-risk assessment of medicinal products in Europe through access to a network of resources working in a transparent and independent manner, and to support to the conduct of non-interventional studies.

While ENCePP provides guidance on methods and governance principles aiming at improving the conduct of non-interventional studies to support regulatory decision-making, ENCePP does not provide a forum for regulating medicinal products nor for assessing their benefits and risks.

Key outputs

Since its establishment ENCePP has produced several key outputs:

  • The former ENCePP Resources Database. Information on data sources, institutions and networks are now available in the HMA-EMA Catalogues of real-world data sources;
  • The former EU PAS Register. Registration of, and search for studies are now available in the HMA-EMA Catalogues of real-world data studies;
  • The ENCePP Guide on Methodological Standards in Pharmacoepidemiology: a resource for methodological guidance in pharmacoepidemiology;
  • The ENCePP Code of Conduct: a set of rules and principles for pharmacoepidemiology and pharmacovigilance studies to promote transparency and scientific independence throughout the research process;
  • The ENCePP Checklist for Study Protocols: a tool to promote the quality of studies through study design;
  • Support to public health emergencies (e.g., during the COVID-19 pandemic through methods and selection of suitable data sources, and recommendations for registration of studies);
  • Publications in peer-reviewed journals and reference in regulatory and non-regulatory guidelines and scientific publications;
  • Contribution of the ENCePP community to multiple research projects and guideline developing activities (e.g., ICH).